A High concentration of glutathione is present in the eye lens, where it performs the function of an essential antioxidant, which is very important for maintaining the tissue's transparency. Thus it acts as a protection against cataracts.
In combination with an active glutathione redox cycle placed in the lens epithelium and superficial cortex, GSH detoxifies potential damaging oxidants such as H2O2 and dehydroascorbic acid.
According to studies conducted recently, it has been indicated that, independent of the cells' ability to detoxify H2O2, GSH has an important hydroxyl radical-scavenging function in lens epithelial cells.
Lower level of GSH leads to damage of the lens epithelial targets such as Na/K-ATPase, certain cytoskeletal proteins and proteins associated with normal membrane permeability, by low levels of oxidant.
The nucleus of the lens has relatively low levels of glutathione, and is most common in the lens of aging persons. However, the exact procedure of how the compound travels from the epithelium to the central region of the organ is yet not known.
The nucleus becomes especially vulnerable to oxidative stress due to relatively low ratio of GSH to protein -SH in the nucleus of the lens along with low activity of the glutathione redox cycle in this region. This has been demonstrated in a recent study with the use of in vivo experimental animal models such as hyperbaric oxygen, UVA light and the glutathione peroxidase knockout mouse.
Thus the studies indicated that high levels of glutathione can help in protecting our eye lens from developing cataract.
MaxGXL has been proven to raise glutathione levels by approximately 250-400% in humans as proven by tests in lymphocytes.
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